Senior/Executive Director overseeing Immunology & Inflammation projects at Orum Therapeutics. Leading project teams and providing strategic direction from discovery through clinical development.
Responsibilities
Lead the I&I TA; working closely with strategic thought partners, build the capability of I&I at Orum, and develop the resourcing strategy
In collaboration with Orum leadership, lead development of I&I corporate-level strategy and provide guidance as appropriate
Lead and mentor I&I Project/Program Lead(s) as the TA grows
Lead internal and external experts (Biology, Chemistry, DMPK, Toxicology, etc.) to achieve project/program goals as one cross-functional team
Drive formation of the project/program’s integrated development strategy, develop alternative strategies
Identify risks and develop mitigation plans
Oversee execution of the integrated development strategic plan
Ensure that the right assays, animal models and human-based ex vivo platforms are used to de-risk the projects/programs
Manage and monitor CRO activities to drive project momentum
Design robust target validation and biomarker strategies throughout the project lifecycle to drive successful transitions from pre-clinical proof-of-concept to human clinical trials
Identify resource gaps to meet aggressive timelines
Hold matrixed team members accountable to their responsibilities
Drive the application of immunological methods to understand disease mechanisms and therapeutic interventions
Serve as a key thought leader in immunology; generate new therapeutic hypotheses and guide the scientific direction of project/program efforts
Make data-driven decisions and pivot strategies with agility
Stay at the forefront of emerging science and modalities in the I&I field
Keep abreast of and understand competitive advancements that may influence strategic planning for Orum assets
Serve as the primary point of contact for external partners, scientific advisory boards, etc.
Represent Orum’s I&I projects/programs at major scientific conferences, with prospective partners, and in due diligence discussions
Foster a culture of transparency and accountability
Use a culture of feedback to strategically align the team
Proactively act as a mentor to junior project/program leads and scientists, empowering them to direct their own paths in alignment with Orum’s core values
Requirements
PhD or equivalent in Immunology, Cell Biology, or a related life science field
12+ years of experience in the biotech/pharma industry, with at least 8 years in a cross-functional project/program team leadership role.
Thorough comprehension of the I&I landscape critical; experience developing therapeutics for autoimmune and inflammatory diseases is preferred
Deep knowledge of B cell, T cell, and innate immune cell biology, cytokine signaling, and immune tolerance
Experience with ADCs, TPDs, or PROTACs is highly preferred
Experience leading projects/programs that have successfully entered clinical development
Ability to translate complex science into actionable business strategies
Exceptional interpersonal and presentation skills; ability to communicate and influence at the executive level, and navigate complex technical debates with humility and tact.
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