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Onsite Lead Scientist, Protein Engineering
Posted 5 days ago
About the role
- Lead Scientist in protein engineering at Zealand Pharma, responsible for protein characterization and guiding compound design. Collaborating across teams to advance innovative peptide-based drugs.
Responsibilities
- Lead and execute design, expression, purification, reconstitution and characterization of proteins to support our drug discovery projects
- Deliver high quality protein and participate in biochemical, biophysical or structural studies to drive the understanding of structure activity relationships and peptide candidate selection
- Ensure high quality protein and data generation, analysis, interpretation, and reporting – both for internal data and data generated through CROs or partners
- Provide guidance to cross-functional teams, integrating with both medicinal chemistry, in vitro pharmacology data, and knowledge on metabolism and obesity
Requirements
- Ph.D. in Biochemistry, Molecular pharmacology, Molecular biology, or a related field with at least 6 years of post-Ph.D. experience
- Strong experience with expression, purification and reconstitution of mammalian membrane proteins
- Experience and sound understanding of protein quality control, including protein integrity, stability, and formulation impact performance and data interpretation
- Expertise with peptide–protein interactions on membrane proteins, crude or purified
- Hands on experience with biophysical platforms like SPR, BLI, ITC, DSF to determine binding affinities and kinetics of compound/receptor interactions
- Knowledge of Cryo-EM workflow or similar
- Strong collaboration and communication skills, with the ability to work effectively in cross functional project teams
- Experience with working with CROs and partners.
Benefits
- Competitive salary
- Flexible work hours
- Health insurance
- Professional development opportunities
- Mentorship and guidance
Job title
Job type
Experience level
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Not specified
Degree requirement
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