Localization Specialist localizing content for German - speaking audiences. Joining Preply to create world - class localized experiences for learners and tutors globally.
AM
Onsite Senior Scientist – Computational Discovery, Translational Analytics
Posted yesterday
About the role
- Senior Scientist developing advanced computational methods for target discovery at Amgen. Collaborating with teams to drive drug discovery through innovative technologies.
Responsibilities
- Develop and apply advanced computational methods to enable target discovery, validation, and biomarker identification across multimodal datasets
- Integrate diverse biological data types, including bulk, single-cell, and spatial omics
- Identify cell-type-specific and disease-relevant targets and characterize their cellular context
- Characterize gene function, pathway dependencies, and mechanisms of action
- Develop and apply computational frameworks for variant-to-gene-to-function inference
- Translate computational analyses into clear, testable biological hypotheses
- Collaborate closely with experimental scientists, computational biologists, and cross-functional teams
- Drive digital innovation by identifying gaps in analytical workflows and developing robust solutions.
Requirements
- PhD in computational biology, bioinformatics, statistics, computer science, data science, or a related quantitative discipline [and relevant post-doc where applicable]
- Or Master’s degree and 3 years of directly related experience
- Or Bachelor’s degree and 5 years of directly related experience
- Strong foundation in computational biology methods, including statistical modeling and AI/ML
- Experience working with large-scale biological data, including long-read RNA sequencing, single-cell multi-omics, spatial omics, perturbation screens (e.g., Perturb-seq), translatomics (e.g., Ribo-Seq), proteomics, and/or epigenomic data (e.g., Hi-C, ATAC-seq)
- Proven ability to develop novel computational methods that generate tractable biological insights from integrating complex datasets
- Familiarity with disease tissue biology
- Strong programming skills in Python, R, or similar languages
- Creative, open-minded, and passionate about research.
- Excellent communication and collaboration skills.
Benefits
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions
- group medical, dental and vision coverage
- life and disability insurance
- flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible.
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